Hyperbaric oxygen
Emerging evidenceWhy it might help
Delivering oxygen under increased pressure raises tissue oxygenation and is hypothesized to influence brain regions involved in central pain processing and to support neuroplasticity.
What the research shows
A meta-analysis of four small randomized trials found hyperbaric oxygen was associated with improvements in fibromyalgia impact scores and tender-point counts. However, pooled pain scores were not statistically significant and every trial carried a high risk of bias, so this remains an emerging, not established, option.
Source & what it found
Effectiveness of hyperbaric oxygen for fibromyalgia: a meta-analysis of randomized controlled trials — Frontiers in Medicine (PMC), 2023
Meta-analysis of 4 RCTs (163 participants) showing improved FIQ and tender-point counts but non-significant pooled pain scores and high risk of bias.



