In 122,007 adults undergoing symptom-limited exercise treadmill testing, higher measured cardiorespiratory fitness was associated with lower long-term all-cause mortality in a graded fashion, with elite versus low fitness carrying an adjusted hazard ratio of 0.20 and no upper limit of benefit observed.
How strong the finding is
Very large single-centre retrospective cohort (122,007 adults, 1.1 million person-years, 13,637 deaths, median 8.4 years follow-up) with directly measured rather than estimated fitness, consistent with an earlier meta-analysis of prospective cohorts.
What complicates this
Observational design shows association, not causation. Reverse causality is plausible because subclinical disease lowers fitness. The cohort was clinically referred for testing rather than population-sampled, so absolute risks do not transfer directly to a general wellness membership.
Sources (2)
Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing — JAMA Network Open (2018) · 2018-01-01
Cardiorespiratory fitness as a quantitative predictor of all-cause and cardiovascular mortality: a meta-analysis — JAMA 301(19):2024-2035 · 2009-01-01