In a randomized trial of massage-based decongestive therapy for breast-cancer-related lymphedema, the therapy did not produce a statistically significant reduction in percent excess arm volume compared with a more conservative approach, though it did produce a larger absolute volume loss on one secondary measure.
What complicates this
Mean excess-arm-volume reduction was 29.0% with decongestive therapy versus 22.6% with conservative care, a 6.4% difference that was not statistically significant (95% CI -6.8% to 20.5%, P=.34). Absolute volume loss favored the therapy group (250 mL vs 143 mL, difference 107 mL, P=.03), but that was the only significant outcome, and the authors themselves state they were unable to demonstrate a significant improvement over the conservative approach.
Source
Randomized trial of decongestive lymphatic therapy for the treatment of lymphedema in women with breast cancer — Journal of Clinical Oncology · 2013
