In a meta-analysis of 51 studies, exercising while breathing hyperoxic gas at sea level improved acute exercise performance across modes, with a large effect on time to exhaustion (g = 0.89), small-to-moderate effects on time trials (g = 0.56) and graded exercise tests (g = 0.40), and a small effect on dynamic muscle function (g = 0.28). An inspired oxygen fraction of 0.30 was sufficient.
How strong the finding is
Systematic review and meta-analysis of 51 manuscripts with consistent direction across four test modalities and a dose relationship (r = 0.47 to 0.63) between oxygen fraction and performance gain in most tests.
What complicates this
The effect is within-session, not an adaptation. It was measured in laboratory conditions with controlled inspired oxygen fraction. Studio EWOT delivers an unmeasured fraction through a bag-and-mask system, and effect sizes varied by test mode, with muscle function benefiting least.
Source
The Effects of Hyperoxia on Sea-Level Exercise Performance, Training, and Recovery: A Meta-Analysis — Sports Medicine · 2018-01-01

